What factors influence survival rate?
Factor Example
Nature of cancer -stage
of diagnosis
-growth
fraction
-doubling
time
-heterogeneity
-cell
cycle phase
Pharmacology -time
of treatment initiation
-timing
of treatments
-combination
of drugs used
Patient -state
of health
-location
of blood supply
-ability
to mount immune defense
The cell cycle is an orderly sequence of events that occurs
from the time when a somatic cell is first formed until it divides into two new
cells.
| Influence |
Cell growth kinetics
Several terms describe cell growth kinetics
Cell growth fraction is the proportion of cells in the tumor
dividing or preparing to divide. As the tumor enlarges, the cell growth
fraction decreases because a larger proportion of cells may not be able to
obtain adequate nutrients and blood supply for replication.
Cell cycle time is the average time for a cell that has just
completed mitosis to grow and again divide and again pass through mitosis. Cell
cycle time is specific for each individual tumor.
Tumor doubling time is the time for the tumor to double in
size. As the tumor gets larger, its doubling time gets longer because it
contains a smaller proportion of actively dividing cells owing to restrictions
os space, nutrient availability, and blood supply.
Tumor cell burden is the number of tumor cells in the boy.
Influence
![Influence]()
Reviewed by M H Islam
on
7:40 AM
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